In times of war, the traitor Dou Zhun was in power. Trying to create an elixir of immortality, Dou Zhun and his hirelings used poisonous Gu to experiment on kidnapped village children. Each child is given a number on their back and treated as slave.
After living through years of torture and excruciating experiments, medicine man 19 escaped and was rescued by a maiden Chan Yi. Chan Yi gave him a name Lu Bu and brought him to her village, where she worked as a helper to her elder fellow apprentice. Dou Zhun sent his men to capture Medicine Man 19, in the fight, Chan Yi fell from the cliff, Lu Bu was captured and had his memory suppressed. Lu Bu lost his memory and now is working under Dou Zhun as his adopted son.
Chan Yi survived the fall and three years later she vows to get her revenge on Dou Zhun.